Not as much experience here as some of you, but depending on the salt, there are pros and cons. Using Red Sea Coral pro you do NOT want to mix with warm water first. Wait till it's mostly mixed, and then heat if you want too. Manufacturer will even state the same. I've experienced why. Otherwise I use an Neptune DOS and change through day so my 50G container isn't heated typically. If I plan to do a large change of 40-50G, I will flip the heater on in the container for a few hours.